Sertraline hydrochloride is a prescription medication which is available both as a generic drug and under the brand name Zoloft. Sertraline belongs to a class of drugs known as selective serotonin reuptake inhibitors, or SSRIs. Like other SSRIs, sertraline is believed to work by increasing the brain's supply of the feel-good hormone, serotonin. This corrects an existing chemical imbalance, improving mood and creating a feeling of well-being. Sertraline is most commonly used in the treatment of depression. It can also be effective at treating obsessive-compulsive and social anxiety disorders. Zoloft is available in twenty-five, fifty, and one-hundred milligram tablets. A liquid concentrate is also available. Sertraline should be taken once a day with water, preferably at the same time each day. Once you have been taking this medication regularly, do NOT suddenly stop, as serious withdrawal symptoms can occur. The most commonly reported side effects of sertraline include weight loss, sleepiness, and sexual dysfunction, but please ask your doctor for a complete list. Also, tell your doctor IMMEDIATELY if you experience suicidal thoughts, seizures, or any other significant changes. Sertraline should never be taken with MAO Inhibitors, like Nardil, or with the Tourette's disorder medication, Orap. Ask your doctor for a full list of medications and conditions that should not be combined with sertraline. Zoloft is commonly prescribed and it can help ease the symptoms of people with depression. However, this medication must always be used under the direct care of a physician. Please ask for and review all of the patient information provided by your doctor before taking sertraline.