Prozac can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how Prozac affects you. Do not drink alcohol while using Prozac.

Do not take Prozac if you:

• Are allergic to fluoxetine hydrochloride or any of the ingredients in Prozac. See the end of this Medication Guide for a complete list of ingredients in Prozac.
• Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI.

Do not take an MAOI within 5 weeks of stopping Prozac.

Do not start Prozac if you stopped taking an MAOI in the last 2 weeks.

Before starting Prozac, tell your healthcare provider if you:

• Are taking certain drugs or treatments such as:
• Triptans used to treat migraine headache
• Medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, MAOI's (including linezolid, an antibiotic), or antipsychotics
• Tramadol
• Over-the-counter supplements such as tryptophan or St. John's Wort
• Electroconvulsive therapy (ECT)
• Have liver problems
• Have kidney problems
• Have heart problems
• Have or had seizures or convulsions
• Have bipolar disorder or mania
• Have low sodium levels in your blood
• Have a history of a stroke
• Have high blood pressure
• Have or had bleeding problems
• Are pregnant or plan to become pregnant. It is not known if Prozac will harm your unborn baby. Talk to your healthcare provider about the benefits and risks of treating depression during pregnancy.
• Are breast-feeding or plan to breast-feed. Some Prozac may pass into your breast milk.
• Talk to your healthcare provider about the best way to feed your baby while taking Prozac.